This handbook on ageing management for nuclear power plants (NPPs) has been developed in compliance with relevant IAEA Safety Standards and draws on lessons learned from ageing management practices worldwide. It provides an overview of the topic and guidance on proactive ageing management within NPPs. The publication also collates information on ageing mechanisms, effects on structures, systems and components, the regulatory framework as well as some details on innovative techniques and research and development in the area. The information is presented concisely with clear flow charts and with structured reference to the underlying principles. The handbook will support NPP staff, maintenance managers, vendors, personnel at research organizations and regulators in their work related to the ageing of structures, systems and components.