Infrastructure forms the economic backbone of modern society. It is a key determinant of economic competitiveness, social well-being and environmental sustainability. Yet infrastructure systems (energy, transport, water, waste and ICT) in advanced economies globally face serious challenges. For the first time, a leading team of researchers sets out a systematic approach to making long-term choices about national infrastructure systems. Great Britain is used as a case study to demonstrate how the methodologies and accompanying models can be effectively applied in a national infrastructure assessment. Lessons and insights for other industrialised nations and emerging economies are highlighted, demonstrating practical scenarios for delivering infrastructure services in a wide range of future socio-economic and environmental conditions. The Future of National Infrastructure provides practitioners, policy-makers, and academics with the concepts, models and tools needed to identify and test robust, sustainable, and resilient strategies for the provision of national infrastructure.