Advances in Computers, Volume 114, the latest volume in this innovative series published since 1960, presents detailed coverage of new advancements in computer hardware, software, theory, design and applications. Chapters in this updated release include A Comprehensive Survey of Issues in Solid State Drives, Revisiting VM performance and optimization challenges for big data, Towards Realizing Self-Protecting Healthcare Information Systems: Design and Security Challenges, and SSIM and ML based QoE enhancement approach in SDN context.