This book gathers 14 architects, designers, performing artists, film makers, media theorists, philosophers, mathematicians and programmers. They all argue that matter in contemporary posthuman times has to be rethought in its rich internal dynamism and its multifaceted context. By transversally crossing disciplinary boundaries, new and profound insights into contemporary thinking and creating architecture emerge. Combining the dynamism of materiality and the capacities of nonhuman machines towards prototyping spatiotemporal designs and constructs leads to alternative conceptions of the human, of ethics, aesthetics and politics in this world yet-to-come.