Digital Twins for Healthcare: Design, Challenges and Solutions establishes the state-of-art in the specification, design, creation, deployment and exploitation of digital twins' technologies for healthcare and wellbeing. A digital twin is a digital replication of a living or non-living physical entity. When data is transmitted seamlessly, it bridges the physical and virtual worlds, thus allowing the virtual entity to exist simultaneously with the physical entity. A digital twin facilitates the means to understand, monitor, and optimize the functions of the physical entity and provide continuous feedback. It can be used to improve citizens' quality of life and wellbeing in smart cities and the virtualization of industrial processes.