Hitman Martin Blank's (John Cusack) day goes from bad to worse when he messes up his latest job due to the intervention of his rival, Grocer (Dan Aykroyd). To make amends with his client, Martin has to travel to Grosse Pointe and take out a Federal witness. This trip coincides with his high school reunion, so Martin meets up with his former sweetheart Debi (Minnie Driver), unaware that he is being tailed by two government agents and Felix, another rival assassin who is out for his blood.