In this issue of Infectious Disease Clinics of North America, guest editors Drs. Puja Van Epps and David H. Canaday bring their considerable expertise to the topic of Infections in Older Adults. Of the top ten leading causes of death in older adults, two (influenza and pneumonia, and septicemia) are directly related to infection, and infections likely play an important role in several of the other leading causes of death, as well. In this issue, top experts provide important updates on treating and managing infections, including COVID-19, in older adults. Contains 12 practice-oriented topics including sexually transmitted infections in older adults; resistant bacterial infections in older adults; anticoagulation and COVID-19 in long-term care;  antimicrobial stewardship in older adults; prevention of COVID-19 in older adults; and more.  Provides in-depth clinical reviews on infections in older adults, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.