The articles in this issue give an overview of current issues facing the diagnosis and treatment of diseases involving endocrinology and metabolism. Dr. Rapaport has compiled experts in this field to write state-of-the art clinical reviews on newborn screening, congenital hypothyroidism, neonatal endocrinology, obesity, and the metabolic syndrome in pediatrics. Also included are articles devoted to growth issues, gonadal disorders, and diabetes as well as initiatives to prevent it.