This issue of Physical Medicine and Rehabilitation Clinics, guest edited by Drs. Steven Stanos and James Babington, will discuss Pharmacologic Support in Pain Management. This issue of one of four issues selected each year by series Consulting Editor, Santos Martinez. Topics discussed in this issue include, but are not limited to: Buprenorphine in the management of addiction and pain, Methadone, Anticonvulsants for neuropathic pain, Antidepressants for chronic pain, NSAIDs for acute and chronic pain, Topical analgesics, Muscle Relaxants for acute and chronic pain, Opioid Management: Initiating, Monitoring and Tapering, Integrating CDC Guideline for Prescribing Opioids for Acute and Chronic Pain, Opioid Pharmacology and Side Effect Management, among others.