In this issue of Surgical Oncology Clinics, guest editor Dr. Jason K. Sicklick brings his considerable expertise to the topic of Precision Medicine and Cancer Surgery. Top experts in the field discuss specific surgical areas of precision oncology, such as breast cancer, lung cancer, colorectal cancer, melanoma, and sarcoma, as well as related topics such as immune-oncology, histology, molecular testing, biologics, and targeted therapies. Contains 14 relevant, practice-oriented topics including precision oncology in breast cancer surgery; precision oncology in lung cancer surgery; precision oncology in hepatopancreatobiliary cancer surgery; evolution of precision oncology, personalized medicine, and molecular tumor boards; targeted therapies, biologics, and immunotherapy in the neoadjuvant and adjuvant settings: perioperative risks; and more. Provides in-depth clinical reviews on precision medicine and cancer surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.