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Retrotransposons And Human Disease: L1 Retrotransposons As A Source Of Genetic Diversity (inbunden, eng)

World Scientific Publishing Co

Retrotransposons And Human Disease: L1 Retrotransposons As A Source Of Genetic Diversity (inbunden, eng)

1 292 kr

1 292 kr

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Ons, 19 mar - tor, 20 mar


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Produktbeskrivning

Thirty years ago we knew that retrotransposons made up at least half of our genomes, but little about their role in biology. The human genome has since been sequenced and the position of all retrotransposons in the reference sequence has been determined. However, as of today, the function of retrotransposons still remains elusive.

We know much more about the diseases associated with their movement and the host defenses we all have against them.This volume explores an array of diseases in humans associated with L1 retrotransposon movement within the human genome, including some cancers such as colon cancer and neuropsychiatric disorders such as schizophrenia.The chapters explore the diversity of retrotransposons, their different biological mechanisms, the role of L1 in their movement, and their contribution to human diseases.

This book posits that somatic events caused by retrotransposons have implications for mosaicism and are often associated with cancers. Germline events are common, occur quite early in development, and are a cause of single gene diseases. All in all, the authors implicate L1 retrotransposons as major sources of human diversity and advocate for their continued study.


Format Inbunden Omfång 260 sidor Språk Engelska Förlag World Scientific Publishing Co Pte Ltd Utgivningsdatum 2022-09-14 ISBN 9789811249211

Artikel.nr.

8f638b3a-1b1f-580b-82e7-566c109b3c51

World Scientific Publishing Co

Retrotransposons And Human Disease: L1 Retrotransposons As A Source Of Genetic Diversity (inbunden, eng)

1 292 kr

1 292 kr

Få kvar

Ons, 19 mar - tor, 20 mar


Säker betalning

14-dagars öppet köp


Säljs och levereras av

Buyersclub.se