In 2196 John Canyon (Dennis Hopper) works as a space trucker, independent of the huge corporations and sometimes sailing a little close to the wrong side of the law. His latest job involves taking a sealed cargo safely to Earth, with young trucker Mike Pucci (Stephen Dorff) and sexy waitress Cindy (Debi Mazar). When the trio are taken hostage by the space pirate Captain Macanudo (Charles Dance), they discover the cargo to be a consignment of killer androids.