Therapy Resistance in Prostate Cancer: Mechanisms and Insights, Volume 20 highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and therapies that can be proposed to overcome resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa. Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide, as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies.