This issue of Clinics in Chest Medicine, edited by Dr. Danielle Antin-Ozerkis and Dr. Kristin Highland, is devoted to Thoracic Manifestations of Rheumatic Disease. Topics include: Scleroderma/Mixed Connective Tissue Disease (MCTD); Lupus and APLAS; Sjögren's Syndrome; Rheumatoid Arthritis; Polymyositis/Dermatomyositis; Small Vessel Vasculidities: GPA/MPA/EGPA; Ig4 Related Disease; Spondylarthropathies; Interstitial Pneumonia with Autoimmune Features; Immunosuppressive Therapy (toxicity monitoring, PJP prophylaxis, bone health, immunization, pulmonary drug toxicity); Transplantation (scleroderma, challenges with PRAs, reflux/dysmotility); Biomarkers, Antibodies, and Immunologic Evaluation of the Patient with Lung Disease; Radiology/Imaging of Pulmonary Manifestation of Connective Tissue Disease; and Pulmonary Pathology in Connective Tissue Disease.