This issue of Interventional Cardiology Clinics will explore Transcatheter mitral valve repair and replacement. Curated by the series Editor-in-Chief, Dr. Matthew J. Price, this issue will cover topics and advances in the field that are relevant for practicing clinicians. This issue is one of four selected each year by Dr. Price. The volume will include articles on: Transcatheter Mitral Valve Direct Annuloplasty With the Millipede Device, Transcatheter Mitral Valve Replacement with Intrepid, Transcatheter Mitral Valve Replacement with Tendyne, Treatment of functional mitral regurgitation with transcatheter edge-to-edge repair, Transcatheter Edge-to-Edge repair for Degenerative Mitral Regurgitation, Predicting Left Ventricular Outflow Tract Obstruction Following Transcatheter Mitral Valve Replacement, Prevention and Treatment of Left Ventricular Outflow Tract Obstruction after Transcatheter Mitral Valve Replacement, and Transatrial implantation of transcatheter heart valve for mitral disease, among others.