In this issue of Infectious Disease Clinics of North America, guest editors Drs. Rajesh T. Gandhi and Michael R. Jordan bring their considerable expertise to the topic of Updates on COVID-19. Top experts provide updates on recent advances in diagnosis, treatment, viral protection, and vaccinations, offering infectious disease physicians state-of-the-art clinical and scientific information. With research ongoing and many unanswered questions, this content is key to help stay abreast of current research and clinical information on COVID-19. Contains 9 relevant, practice-oriented topics including next generation COVID-19 vaccines; COVID-19 treatment and management update; clinical manifestations and outcomes of SARS-CoV-2 infection in children and adolescents; the impact of COVID-19 on vulnerable communities; long COVID; and more Provides in-depth clinical reviews on COVID-19 updates, offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews