Aging is associated with an increased prevalence of several GI disorders, including those induced by drugs (eg, gastrointestinal bleeding caused by nonsteroidal anti-inflammatory drugs), anorexia of aging, development of constipation, diarrhea or fecal incontinence, and postprandial hypotension. This issue addresses these disorders and discusses the current treatments for management of these patients. Specifically, articles focus on celiac disease, anorexia of aging, chronic constipation, fecal incontinence, neurogastrointestinal diseases, ischemic gut, and the pharmacology of commonly used GI drugs.