This issue of Interventional Cardiology Clinics, edited by Dr. Marvin H. Eng, will focus on Transcatheter aortic valve replacement. Topics discussed in this issue include, but are not limited to: Choosing between transcatheter heart valves and surgery in a world with low-risk TAVR, Femoral access, hemostasis and vascular complications for TAVR, Balloon expandable Edwards Sapien Transcatheter Heart Valves:? Safety and Efficacy, Conduction Delay and Pacing in TAVR, Mechanical complications of TAVR, Risk and mitigation of coronary obstruction in TAVR, Valve-in-Valve TAVR, Alternative Access for TAVR, Neurological complications in TAVR, Early leaflet thickening, durability and bioprosthetic valve failure in TAVR, Treatment of Bicuspid aortic valve stenosis using transcatheter heart valves, Revascularization in the TAVR population and New Bioprosthetic valve technologies.? Provides in-depth, clinical reviews on transcatheter aortic valve replacement, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.