In a present marked by planetary crisis, a radical rethinking of aesthetics is necessary. This inspirational collection proposes a new way of thinking about aesthetics as fundamental to cultivating more liveable futures. Drawing on the philosophies of Alfred North Whitehead and Félix Guattari, the book develops aesthetics as central to all more-than-human forms of experience, including knowledge practices. Each contribution invites readers on an adventure to explore how this broader view of aesthetics can reshape areas including biomedicine, geological forensics, nuclear waste, race, as well as arts and education. This is an agenda-setting contribution to understanding the significance of aesthetics in science and technology studies, as well social and cultural research more broadly.