This comprehensive text on Python programming is designed for undergraduate and postgraduate students in Computer Science and Information Technology. Whether you are a beginner or have limited programming knowledge, this book offers a structured learning experience, starting from foundational concepts and advancing to complex topics like machine learning. Divided into three parts, the book ensures a smooth progression from Basics and Core concepts of Python to Machine Learning with Python. It covers fundamental topics such as data types, variables, operators, and interactive input-output, enabling readers to write simple yet effective Python programs.