Ironic plot twists and colorful characters abound in Afshin Matin-Asgari's accessible history of relations between the United States and Iran. The missionaries and educators who descended on Iran in the early nineteenth century made way for the next century's oilmen, CIA agents, scholars, and arms dealers in the assertion of US imperial priorities. Whether Iran resisted or succumbed to US interests, it couldn't fail to be shaped by the superpower. Matin-Asgari offers fresh takes on familiar topics: America's rise as a Middle East hegemon during the Cold War; the special relationship between Washington and the shah; the Iranian Revolution and hostage crisis; the Iran-Iraq war; the Islamic Republic's peculiar anti-imperialism; the decades of onerous American sanctions; Israel's intervention in Iran-US relations; the ascendance of Trump; and the 2025 attempt by the United States and Israel to bring regime change to Tehran. A labyrinthine tale of American imperial misadven­tures, Axis of Empire incorporates and challenges scholarly narratives while offering a sophisticated yet highly readable account of Iran-US history.